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Dalcetrapib Advisory Board Meeting
Post-Event Survey
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1. Did the video on the scientific hypothesis of dalcetrapib as introduced by Prof. Chris Packard provide a clear and concise explanation of the proposed scientific hypothesis of dalcetrapib?
*
Yes
No
2. What is your overall feedback on the scientific hypothesis?
*
3. Is there an alternative hypothesis that you would like to propose to explain the interaction of ADCY9, CETP and dalcetrapib?
*
Yes
No
4. Which Mechanism of Action could also explain the potential benefits observed in dal-GenE (tick all that apply):
*
Lipid modulating
Anti-inflammatory
Direct anti-atherosclerotic
NO-mediated effect
Other
5. Assuming the dal-GenE study is positive with at least 15-20% RRR on top of best standard of care:
5a. How important on a scale of 1 to 5 (where 5 is extremely important) is it to have established a MoA to explain the positive results?
*
1
2
3
4
5
5b. What evidence would you need to explain this hypothesis to your peers?
*
6. Regarding the population analyses provided by Julie Hussin:
6a. Do you believe the analyses reveals a genetic interaction between rs1967309 in ADCY9 and rs158477 in CETP?
*
Yes
No
6b. Do you believe the mRNA expression analyses point towards a functional interaction between ADCY9 and CETP on levels of expression of CETP?
*
Yes
No
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