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dalcetrapib Advisory Board Meeting
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1. Did the video on the scientific hypothesis of dalcetrapib as introduced by Prof. Chris Packard provide a clear and concise explanation of the proposed scientific hypothesis of dalcetrapib?
If No, please propose the areas where you consider further explanation to be required:
2. What is your overall feedback on the Scientific Hypothesis?
3. Is there an alternative hypothesis that you would like to propose to explain the interaction of ADCY9, CETP and dalcetrapib?
If Yes please provide details:
4. Which Mechanism of Action (MoA) could also explain any potential benefit of dalcetrapib that may be observed in dal-GenE in 2021 (tick all that apply)
4e. If other please provide details:
5a. Assuming a positive dal-GenE study in 2021: How important on a scale of 1 to 5 (where 5 is extremely important) is it to have established a MoA to explain the positive results?
5b. What evidence would you need to explain this hypothesis to your peers?
5c. Considering other treatment options, where would you rank pharmacogenomic precision medicine with dalcetrapib in your post-ACS treatment strategies?
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